Cholula is generally quite a safe place to be. Keep an eye on your valuables as pickpockets have been known to target absent-minded tourists around the market area. There seem to be a disproportionate amount of stray dogs everywhere, but don´t worry, even though there is always a possibility of rabies, locals say most dogs are harmless. Police patrol the area with the most bars and clubs around 14 Oriente, looking to extract money from drunk students. Avoid driving after a night on the copas and you should be fine.