Bus is by far the most common mode of transportation in Bolivia (Funny, considering the lack of attention paid to keep the roads in decent condition!). Expect a bumpy ride, though the drivers and other passengers are always friendly and helpful to travelers. From La Paz you will be able to bus anywhere in the country, leaving from the terminal, the cemetery district, or Villa Fatima. From other cities you might need to backtrack back to La Paz, though Uyuni, Sucre, Cocabamba, and Santa Cruz offer thorough services too.

Overnight buses are common, as it often takes a long while to get a short distance. Bus companies offer a number of options, including cama and semi-cama, though this just refers to how far back your chair reclines. International buses run from La Paz and the border towns, and they are often higher quality than local buses and worth the extra few Bolivianos for their convenience and amenities.