Pickpockets are a problem in Potosí. Take care in crowded areas, restaurants and internet cafes. There have been some cases of muggings in taxis. Use registered taxis (normally these have a sign with the name of the company and number on top of the car) and be vigilant at all times. Report any crimes to the Tourist Police, located on the Plaza.

The mines can be dangerous. At an altitude of 4,200 meters and with temperatures ranging from below freezing to over 45ºC (113ºF), as well as heavy wagons and narrow, enclosed spaces, they are fully-operating environments and risks are involved. Those who suffer from claustrophobia or have respiratory problems such as asthma should be particularly careful and may even want to reconsider taking a tour.