The Jesuit Missions can be visited in a loop, starting and finishing in Santa Cruz. There are regular buses that head north along the paved road to San Xavier then head east to ConcepciÃ³n and San Ignacio. From here you can hire a taxi for the day to visit the smaller missions to the south (Santa Ana, San Rafael and San Miguel). There are also daily buses to these settlements if you have plenty of time.
A dirt road then heads south roughly 200 kilometers to San JosÃ© de Chiquitos, from where you can take a train, or bus if you really have to, back to Santa Cruz (unfortunately, train tickets on this route can be a little hard to come by so you might have to take the bus). You could also choose to do the trip the other way around, starting with the scenic train journey to San JosÃ© (it should be easier to buy train tickets in Santa Cruz than it is in San JosÃ©) and maybe take a few days to relax in the beautiful ConcepciÃ³n near the end of your trip.
Another option is to hire a car in Santa Cruz and drive the route yourself â€“ a great alternative if thereâ€™s a few of you. The trip will take you about a week and keep in mind that most of the roads arenâ€™t paved so itâ€™s not advisable to go in the rainy season. Thereâ€™s also a shortage of petrol stations outside of the major settlements, so be prepared. There are some small regional airports in San Ignacio, San JosÃ© and ConcepciÃ³n, with irregular charter flights. There are also tour companies that can organize trips around the Jesuit Mission circuit.