Buses from Trinidad to San Ignacio de Moxos ($4.50) leave daily from outside the Trinidad bus terminal. The journey can take as little as 3.5 hours, but can last as long as 12 hours in the rainy season, if the road is passable at all. The journey involves river crossings on a wooden barge, which carries car, buses and trucks. Camionetas also leave every day from Avenida Mamoré, near Avenida Santa Cruz, in Trinidad. In the rainy season or festival times (July 31 and Easter week) there are regular airtaxis (around $100 return).
To head west from San Ignacio de Moxos, you can buy tickets on through buses to Rurrenabaque and San Borja, but you’ll need to buy your ticket in advance.
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