As always, when traveling through the Norte Grande take care to keep your money hidden and avoid toting around expensive items that may catch a curious eye. If you stray from well-populated areas, it's best to take a cab. Overall, use a little common sense and you'll be fine.

In fact, Mother Nature is probably your biggest threat in the Norte Grande. The sun is very powerful, so always carry a high SPF sunscreen. And the Atacama is indeed the driest desert in the world, so stay hydrated! Finally, when exploring the highlands, make sure that you have the proper equipment that will protect you from the elements. When in doubt, travel with a guide.