The towns in the Southern Andes are all relatively small, and since there seems to be a correlation between big cities and crime, the towns and villages in this region tend to be pretty safe. When traveling on buses, make sure to always keep an eye on your personal belongings. Luggage placed under the bus or on the roof should be fine, but keep your day pack close. Crowded buses present the most problems, as pickpockets have an easier time when everyone is packed together. In general, take common-sense precautions and you should not have any issues.
Due to the heights of the towns in the Southern Andes, you may encounter some altitude sickness, including shortness of breath, dizziness and fatigue. Make sure you give yourself some time to acclimate, depending on where you are arriving from. Chewing on or making a tea with coca leaves generally relieves the symptoms.
Here are some related tips to help plan your trip to Southern Peruvian Andes : When To Go and Highlights.
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